n methyl pyrrolidone toxicity

    METHOD OF ANALYSIS - fda

    N –methyl–2-pyrrolidone (NMP) in edible tissues of cattle was developed as required by 512(d)(1)(I) of the Federal Food, Drug, and Cosmetic Act (21 U.S.C. 360b(d)(1)(I)) and is codified

    1. Identification - Fisher Scientific

    1-Methyl-2-pyrrolidone 872-50-4 99 4. First-aid measures General Advice Show this safety data sheet to the doctor in attendance. Immediate medical attention is required. Eye Contact Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Immediate medical attention is required.

    ASSESSMENT OF REPRODUCTIVE TOXICITY AND …

    Objectives: N-methyl-2-pyrrolidone (NMP) is a solvent used in petrochemical, electric and electronic industries, and in the production of paint removers, pesticides and veterinary drugs. The substance exhibits slight acute toxicity, and mod-erate irritant, embryotoxic and teratogenic effects.

    METHYL PYRROLIDONE || Skin Deep® Cosmetics Database | EWG

    About METHYL PYRROLIDONE: Methyl Pyrrolidone is a substituted heterocyclic organic compound. Function(s): Solvent; SURFACTANT

    n methyl pyrrolidone toxicity,

    2,4-D - toxicity, ecological toxicity and regulatory .

    N-methyl-2-pyrrolidone - Identification, toxicity, use, water pollution potential, ecological toxicity and regulatory information. This database and website are updated and enhanced by Pesticide Action Network North America (PANNA). The project is made possible by our Sponsors and by PANNA general funds. We need your support to maintain and improve this system. Please support the database and …

    N‐Methyl‐2‐pyrrolidone (vapour) [MAK Value Documentation .

    In an additional experiment to determine purely dermal uptake of N‐methyl‐2‐pyrrolidone, volunteers were exposed to constant N‐methyl‐2‐pyrrolidone concentrations of 80 mg/m 3 in an exposure chamber while the inhalation of N‐methyl‐2‐pyrrolidone was prevented by a face mask that provided filtered fresh air. The exposure was carried out both without and with temporary physical activity on a bicycle …

    Haz-Map Category Details - National Institutes of Health

    Evaluation of exposure biomarkers from percutaneous absorption of N-methyl-2-pyrrolidone. Scand J Work Environ 2004;30(4):306-312] In high-dose animal studies, adverse effects include CNS depression and changes to the liver, kidneys, and blood cells.

    N-Methyl-Pyrrolidone Product Safety Summary - dupont

    N-Methyl-Pyrrolidone is a clear, colorless liquid with a boiling point of 204 °C and a melting/freezing point of -24.2 °C. NMP is non-explosive but is a combustible liquid with its flammability derived from its flash point of 91°C. NMP has a self-ignition temperature …

    N-Methylpyrrolidone(NMP) (NMP) - cdph

    It is toxic to the reproductive system of male and test animals. The reproductive effects of NMP have not been studied in humans. Based on the animal tests, you should treat NMP as a potential human reproductive hazard. Overexposure to NMP irritates the eyes, . Safety-Kleen™ N-Methyl Pyrrolidone Soy Strip Marine.

    Toxicity of N-methyl-2-pyrrolidone (NMP . - ScienceDirect

    No life-shortening toxic or carcinogenic effects were observed in rats exposed for 2 years to 0.04 or 0.4 mg/liter of NMP. 987 Society of Toxicology. N-Methyl-2-pyrrolidone (NMP) is a polar solvent which is miscible in water, ethyl alcohol, ether, chloroform, benzene, ethyl …

    Methyl (N-) Pyrrolidone, CP - columbuschemical

    n-Methyl Pyrrolidone >99 872-50-4 212-828-1 C 5 H 9 NO 99.13 g/mol 4. FIRST-AID MEASURES Eyes Rinse with plenty of water for at least 15 minutes and seek medical attention. Inhalation Move casualty to fresh air and keep at rest. If breathing is difficult, give oxygen. If not breathing, give artificial respiration. Get medical attention.

    N-Methylpyrrolidone | CAS#:872-50-4 | Chemsrc

    Chemsrc provides N-Methylpyrrolidone(CAS#:872-50-4) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of N-Methylpyrrolidone are included as well.

    N-Methyl-2-Pyrrolidone MATERIAL SAFETY DATA SHEET …

    methyl-2-pyrrolidinone at a concentration of 1 mg/L as an aerosol for 10 days showed depletion of hematopoietic cells in the bone marrow and atrophy of the lymphoid tissues of the thymus, spleen, and lymph nodes. Bone marrow - Irregularities - Based on Human Evidence SECTION 12: Ecological information 12.1 Toxicity Toxicity to fish Toxicity to .

    N-Methyl-2-pyrrolidone - Wikipedia

    N -Methyl-2-pyrrolidone. It is miscible with water and with most common organic solvents. It also belongs to the class of dipolar aprotic solvents such as dimethylformamide and dimethyl sulfoxide. It is used in the petrochemical and plastics industries as a solvent, exploiting its nonvolatility and ability to dissolve diverse materials.

    Risk Management for N-Methylpyrrolidone (NMP) | US EPA

    N-Methylpyrrolidone (NMP) is a solvent used in a variety of industries and applications, such as paint and coating removal, petrochemical processing, engineering plastics coatings, agricultural chemicals, electronic cleaning and industrial/domestic cleaning. NMP is …

    MATERIAL SAFETY DATA SHEET - Imperial College London

    MATERIAL SAFETY DATA SHEET This product is classified as hazardous based on Directive 67/548/EEC (as amended) or Directive 1999/45/EC of the Commission of the European Communities Printing date : 05-2001 1 / 7 N-METHYLPYRROLIDONE 1.1 Identification of …

    N-methyl-2-pyrrolidone: Carcinogenic Potency Database

    Oct 03, 2007· N-Methyl-2-pyrrolidone: All Experiments and Citations in CPDB The definition of each code in the plot below will appear in a pop-up window when the field name in the header line is clicked, e.g., Strain, Site, Path .

    N-methyl-2-pyrrolidone: Carcinogenic Potency Database

    Oct 03, 2007· N-methyl-2-pyrrolidone Results in the Carcinogenic Potency Database. The Carcinogenic Potency Database (CPDB) is a unique and widely used international resource of the results of 6540 chronic, long-term animal cancer tests on 1547 chemicals.

    N-Methylpyrrolidone | CAS#:872-50-4 | Chemsrc

    Chemsrc provides N-Methylpyrrolidone(CAS#:872-50-4) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of N-Methylpyrrolidone are included as …

    n-Methylpyrrolidone | OEHHA

    Specific Regulatory Levels: Reproductive Toxicants (2,4-D butyric acid, m-dinitrobenzene, hydramethylnon and N-methylpyrrolidone) Notice of Revised Time for the Public Hearing for Proposed Amendments to Title 22, California Code of Regulations, Section 12805, Specific Regulatory Levels: Chemicals Causing Reproductive Toxicity

    N-Methyl-2-pyrrolidone | Sigma-Aldrich

    Summary: N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning.

    SAFETY DATA SHEET - VWR International

    SAFETY DATA SHEET N-Methylpyrrolidone 000000011705 Page 1 / 14 . Reproductive toxicity, Category 1B Specific target organ toxicity - single exposure, Category 3, . N-methyl-2-pyrrolidone 872-50-4 100.00 % SECTION 4. FIRST AID MEASURES Inhalation : Remove to fresh air. If not breathing, give artificial respiration.

    Fact Sheet: N-Methylpyrrolidone (NMP) | Assessing and .

    N-Methylpyrrolidone, also known as NMP or 1-methyl-2-pyrrolidone, is a solvent used in a range of products. The average consumer is most likely to encounter it in paint strippers, even though safer alternatives exist. NMP has been closely linked to developmental impacts including miscarriages.

    N-METHYL-2-PYRROLIDONE | CAMEO Chemicals | NOAA

    Methyl 2-pyrrolidinone, 1-; (N-Methylpyrrolidone) (872-50-4) 30 ppm : 32 ppm : 190 ppm

    n-Methylpyrrolidone | OEHHA

    Specific Regulatory Levels: Reproductive Toxicants (2,4-D butyric acid, m-dinitrobenzene, hydramethylnon and N-methylpyrrolidone) Notice of Revised Time for the Public Hearing for Proposed Amendments to Title 22, California Code of Regulations, Section 12805, Specific Regulatory Levels: Chemicals Causing Reproductive Toxicity

    Home Page [productcatalog.eastman]

    Product Description. N-Methyl-2-Pyrrolidone (NMP) is a high boiling, polar aprotic, low viscosity liquid. NMP has a good solvency for a wide range of organic and inorganic compounds and it is miscible with water at all temperatures and has a high chemical and thermal stability.

    N Methyl 2 Pyrrolidone Manufacturers, SDS - mubychem

    Toxicity to bacteria LC50 - Bacteria - > 9,000 mg/l (N-methyl-2-pyrrolidone) Results of PBT and vPvB assessment : This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very …

    Solubility Improvement of Drugs using N-Methyl Pyrrolidone

    Feb 20, 2008· N-methyl pyrrolidone (NMP) is a water miscible, aprotic solvent with a log K ow of −0.54. It has been reported to increase the solubility and permeability of several drugs (1–4). It has low toxicity both orally and parenterally . It is thermally stable (boiling point 202 °C) and can be used in formulations that require heat sterilization.

    n methyl pyrrolidone toxicity,

    MATERIAL SAFETY DATA SHEET - Imperial College London

    MATERIAL SAFETY DATA SHEET This product is classified as hazardous based on Directive 67/548/EEC (as amended) or Directive 1999/45/EC of the Commission of the European Communities Printing date : 05-2001 1 / 7 N-METHYLPYRROLIDONE 1.1 Identification of …

    1-methyl-2-pyrrolidone - Substance Information - ECHA - Europa

    Substance Information. Substance information. . Potentially toxic to reproduction: comes from a harmonised C&L classifying the substance as suspected toxic to reproduction Repr. 2. Broad agreement: comes from industry data where a majority of data submitters agree the substance is toxic to reproduction. . N-methyl pyrrolidone . Registration .

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